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Even at therapeutic doses, dogs may show clinical signs of vomiting, depression, and vocalization.

With overdose, the severity of CNS signs can be substantial and may include dysphoria, lateral recumbency, or coma.

Dosages are adjusted in horses to maintain serum concentrations of 5–10 mcg/m L.Muscle spasticity is a characteristic of many clinical conditions, including trauma, myositis, muscular and ligamentous sprains and strains, intervertebral disc disease, tetanus, strychnine poisoning, neurologic disorders, and exertional rhabdomyolysis.An increase in tonic stretch reflexes originates from the CNS with involvement of descending pathways and results in hyperexcitability of motor neurons in the spinal cord.It has no discernible effects on respiratory and cardiac function but can cause dizziness and sedation.In veterinary medicine, is used to treat malignant hyperthermia in various species, porcine stress syndrome, equine postanesthetic myositis, and equine exertional rhabdomyolysis (see Malignant Hyperthermia and see Exertional Myopathy in Small Animals).

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